LONG-ACTING ERWINIA CHRYSANTHEMI, PEGCRISANTASPASE, INDUCES ALTERNATE AMINO ACID BIOSYNTHETIC PATHWAYS IN A PRECLINICAL MODEL OF PANCREATIC DUCTAL ADENOCARCINOMA

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy.Targeting PDAC metabolism through amino acid restriction has emerged as a promising new strategy, with asparaginases, enzymes that deplete plasma glutamine and asparagine, reaching clinical tri

The article focuses on the anti-peasant activities of the All-Russian Extraordinary Commission for Combating Counter-Revolution, Speculation, and Sabotage organs in the Volga Region and in the Ural Region during the Civil War.The peasantry of the South-East of the European Russia that suffered a humanitarian catastrophe due to the ruinous politics

The COVID-19 pandemic has highlighted the profound impact Fencing Materials of the SARS-CoV-2 virus as a significant threat to human health.There is an urgent need to develop a comprehensive understanding of the current outbreak by studying the dynamics of the virus within the human body.In this research, we present a mathematical model that explor

This Electric Fans paper departs from the problem of the conspiracy between capitalism and imperialism and modern colonialism which has become a powerful force to exploit the environment in order to meet the demands of industrialization and modernization of society in capitalist countries.Some research questions that will be answered in this paper